LANCASTER, CA, December 27, 2005 - Simulations Plus, Inc. (AMEX: SLP), a leading provider of simulation and modeling software for pharmaceutical discovery and development, announced that it has released version 4.0 of its ClassPharmerTM software product.

Dr. David Miller, senior scientist and product manager for ClassPharmer at Simulations Plus, said: "This release marks a major milestone in this new business area for Simulations Plus. Our acquisition of the former ClassPharmer software last November, combined with the acquisition of Sage Informatics' ChemTK software, paved the way for this completely new version of ClassPharmer. Major revisions in the algorithms, coupled with a transition to a faster programming language, resulted in a ten- to thousand-fold speed increase in critical tasks such as substructure matching, predictive model generation, and chemical class identification. With version 4.0, it is now possible to perform detailed analyses of thousands of molecules in just minutes, versus hours or days using the previous version."

Walt Woltosz, chairman and chief executive officer of Simulations Plus, added: "We've visited nearly 20 companies in February and March to show the beta version of ClassPharmer 4.0. Without exception, every scientist that saw it wants it. Dr. Miller has done a remarkable job in a few short months to develop a greatly enhanced version of ClassPharmer that will increase our customers' productivity by an order of magnitude or more"


About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery and development simulation software, which is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies worldwide. The Company's Words+ subsidiary produces assistive technology and communication devices for persons with disabilities. Â The Company also produces a line of educational simulation software under the umbrella name FutureLabTM, which is based on its proprietary software technologies. Simulations Plus, Inc., is headquartered in Southern California. For more information, visit our Web sites at www.simulations-plus.com and www.words-plus.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 - With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. The actual future results of the Company could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: the ability of the Company to continue to book revenues and earnings in accordance with existing accounting standards, the ability of the Company to maintain its competitive advantage, the general economics of the disability and pharmaceutical industries, the ability of the Company to attract and maintain sufficient scientific and technical staff to sustain its R&D and customer support functions, and a sustainable market. Further information on the Company's risk factors is contained in the Company's quarterly and annual reports as filed with the Securities and Exchange Commission.


For further information:
Simulations Plus, Inc.
42505 10th Street West
Lancaster, CA
93534-7059 USA
www.simulations-plus.com
CONTACT: investor relations:
Contact: Renee Bouche