LANCASTER, CA, August 8, 2006 - Simulations Plus, Inc. (AMEX: SLP) announces that Walt Woltosz, chairman and CEO, will be live on Market News First (mn1.com) for an exclusive interview with the MN1 radio team. The interview is set for Wednesday, August 9, 2006, at 2:00 p.m. EDT.

Simulations Plus is a leading developer of simulation and modeling software for pharmaceutical discovery and development, and a leading consulting firm to the industry in the areas of oral drug absorption and pharmacokinetics. The company's software addresses three critical needs in pharmaceutical R&D: (1) Predicting the properties of new potential drug molecules from their structure, (2) analyzing high throughput screening data to find common molecular structural characteristics associated with measured properties, and (3) simulating how drugs are dissolved, absorbed, and distributed into different tissues in humans and in animals. These tools enable researchers to avoid unnecessary experiments in the lab and in animals, and they provide a means for understanding complex experimental results. The Company's software products and consulting services are used by about 60 companies in the U.S., Europe, and Japan.

To learn more about Simulations Plus, log on to MN1.com and join company CEO Walt Woltosz as he talks about the company's goals.


About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery and development simulation software, which is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies worldwide. The Company's Words+ subsidiary produces assistive technology and communication devices for persons with disabilities. The Company also produces a line of educational simulation software under the umbrella name FutureLab(TM), which is based on its proprietary software technologies. Simulations Plus, Inc., is headquartered in Southern California. For more information, visit our Web sites at www.simulations-plus.com and www.words-plus.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 - With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. The actual future results of the Company could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: the ability of the Company to continue to book revenues and earnings in accordance with existing accounting standards, the ability of the Company to maintain its competitive advantage, the general economics of the disability and pharmaceutical industries, the ability of the Company to attract and maintain sufficient scientific and technical staff to sustain its R&D and customer support functions, and a sustainable market. Further information on the Company's risk factors is contained in the Company's quarterly and annual reports as filed with the Securities and Exchange Commission.


About MN1.com

Market News First is an online market news provider which brings investors current news on the market. Market News First is the only online live radio web site that brings real market news to investors and features live interaction with companies from the Bulletin Board to NYSE. Through its daily live one-on-one interviews with the presidents and CFOs of established companies, Market News First provides insight into the companies' current situations and future plans and keeps investors informed of the newest opportunities in the market.


For further information:
Simulations Plus, Inc.
42505 10th Street West
Lancaster, CA
93534-7059 USA
www.simulations-plus.com
CONTACT: investor relations:

Contact: Renee Bouche