LANCASTER, CA, January 15, 2009 – Simulations Plus, Inc. (NASDAQ: SLP), a leading provider of simulation and modeling software for pharmaceutical discovery and development, today reported financial results for its first fiscal quarter of fiscal year 2009 ended November 30, 2008 (1QFY09).

Ms. Momoko Beran, chief financial officer of Simulations Plus, stated: “I’m pleased to report that in spite of the global economic crisis that has dominated the media during our first quarter, we set a new first quarter record for both revenues and earnings. Consolidated net sales increased 7.5% to $2,133,000 in 1QFY09 from $1,984,000 in the first fiscal quarter of fiscal year 2008 (1QFY08), which had been the previous record first quarter by a large margin. Pharmaceutical software and services revenues for 1QFY09 were nearly identical with 1QFY08 at $1,430,000 as compared with $1,438,000 in 1QFY08, a slight decrease of $8,000, or 0.6%. It’s worth noting that this was achieved in spite of $260,000 in software license renewal revenues that shifted out of the quarter, either being received earlier in 4QFY08 or slipping to 2QFY09. Revenues from our Words+ subsidiary were $703,000 in 1QFY09, an increase of $158,000 or 29.0% from $545,000 in 1QFY08.”

Ms. Beran continued: “For 1QFY09, consolidated gross profit increased 7.3% to $1,607,000 from $1,498,000 in 1QFY08. R&D expense increased 33.4% to $301,000 in 1QFY09 from $226,000 in 1QFY08; and total R&D expenditures, which include capitalized software development costs, increased by 25.8%, primarily due to expansion of our Life Sciences staff and salary increases. Consolidated SG&A decreased 2.9% to $904,000 in 1QFY09, compared to $930,000 in 1QFY08. As a percentage of sales, SG&A decreased to 42.4% in 1QFY09 from 46.9% in 1QFY08. For 1QFY09, net income before taxes increased 11.8% or $48,000 to $453,000 compared with $405,000 in 1QFY08. The provision for income taxes decreased by 12.9% to $141,000 for 1QFY09 from $162,000 in 1QFY08. Using our best estimates for the additional revenues and profits we expect during the remainder of the year, we anticipate a tax rate for the year of about 32 ~ 38%, which will depend on the amount of R&D tax credits generated during the current fiscal year.

“Consolidated net earnings for 1QFY09 increased over 28% to $312,000, or $0.02 per diluted share, as compared to $243,000, or $0.01 per diluted share for 1QFY08. Our cash continues to grow, with cash at the end of 1QFY09 of $6,814,000 including the $750,000 in ARSs held in our UBS account (which were purchased at face value plus interest by UBS on January 2, 2009), a 49% increase from $4,584,000 at the end of 1QFY08. Shareholders’ equity increased by 4% during the first quarter to $10,315,000 from $9,915,000.”

Walt Woltosz, chairman and chief executive officer of Simulations Plus, said: “We’re very pleased with our first quarter results, not only because it sets new records for revenues and earnings, but because in light of the global economic situation, Simulations Plus continues to thrive and grow. Last year’s first quarter was a significant jump over the previous highest first quarter – almost 48%. We matched that and exceeded it in spite of the current climate, and we increased earnings by over 28%. We believe our emphasis on product quality and strong customer support is serving us well. Our team continues to enhance our best-in-class software offerings, and we continue to move ahead nicely on our funded collaborations, which will add new capabilities and markets for GastroPlus™ and ADMET Predictor™. We’re financially strong, with more cash in the bank than at any time in our history. We continue to seek good acquisition opportunities. While we’re cautiously optimistic that we will close one or more in the coming months, there can be no assurances that any will be completed.”

About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery and development simulation software, which is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies worldwide. We have two other businesses that are based on our proprietary technologies: a wholly owned subsidiary, Words+, Inc., which provides assistive technologies to persons with disabilities as well as a personal productivity tool for the mass market called Abbreviate!; and an educational software series for science students in middle and high schools known as FutureLab. For more information, visit our Web sites at www.simulations-plus.com and www.simulations-plus.com

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 – With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. Words like “believe”, “expect” and “anticipate” mean that these are our best estimates as of this writing, but that there can be no assurances that expected or anticipated results or events will actually take place, so our actual future results could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: our ability to maintain our competitive advantages, acceptance of new software and improved versions of our existing software by our customers, the general economics of the pharmaceutical industry, our ability to finance growth, our ability to continue to attract and retain highly qualified technical staff, our ability to identify and close acquisitions on terms favorable to the Company, and a sustainable market. Further information on our risk factors is contained in our quarterly and annual reports as filed with the Securities and Exchange Commission.



SIMULATIONS PLUS, INC. AND SUBSIDIARY

CONSOLIDATED BALANCE SHEET

November 30, 2008 (Unaudited ) and August 31, 2008 (Audited)



ASSETS

November 30, 2008

August 31, 2008

Current assets

Cash and cash equivalents

$ 6,063,754

$ 5,889,601

Accounts receivable, net of allowance for doubtful accounts

and estimated contractual discounts of $388,125 and $319,609

2,474,455

2,105,074

Inventory

337,259

342,051

Prepaid expenses and other current assets

125,334

195,330

Deferred income taxes

340,600

318,400

Total current assets

9,341,402

8,850,456

Investment

750,000

750,000

Capitalized computer software development costs ,

net of accumulated amortization of $3,448,159 and $3,324,328

1,866,574

1,788,756

Property and equipment , net

94,373

102,633

Customer relationships , net of accumulated amortization of $90,515 and $85,029

37,527

43,013

Other assets

18,445

18,445

Total assets

$12,108,321

$11,553,303

LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities

Accounts payable

$ 165,454

$ 181,230

Accrued payroll and other expenses

563,607

537,363

Accrued bonuses to officer

83,845

60,000

Accrued warranty and service costs

41,145

33,899

Accrued income tax

128,633

-

Deferred revenue

33,333

83,333

Total current liabilities

1,016,017

895,825

Long-Term liabilities

Deferred income taxes

777,300

742,400

Total liabilities

1,793,317

1,638,225

Commitments and contingencies

Shareholders' equity

Preferred stock, $0.001 par value

10,000,000 shares authorized, no shares issued and outstanding

-

-

Common stock, $0.001 par value

50,000,000 shares authorized

16,406,400 and 16,297,400 shares issued and outstanding

4,878

4,769

Additional paid-in capital

6,416,280

6,328,185

Retained Earnings

3,893,846

3,582,124

Total shareholders' equity

10,315,004

9,915,078

Total liabilities and shareholders' equity

$12,108,321

$11,553,303



For further information:
Simulations Plus, Inc.
42505 10th Street West
Lancaster, CA
93534-7059 USA
www.simulations-plus.com
CONTACT: investor relations:
Contact: Renee Bouche