LANCASTER, CA, July 11, 2006 - Simulations Plus, Inc. (AMEX: SLP), a leading provider of ADMET absorption simulation and neural net structure-to-property prediction software for pharmaceutical discovery and development, today reported its financial results for the third fiscal quarter of its 2006 fiscal year ended May 31, 2006.

Ms. Momoko Beran, chief financial officer of Simulations Plus, stated: "Consolidated revenues for the third quarter were $1,788,000, an increase of 25.6% from $1,424,000 in the third quarter of fiscal year 2005, which had set the previous record for third quarters. Revenues from pharmaceutical software and services were $1,097,000, an increase of 65.5% from $663,000 in the third quarter of fiscal year 2005. Revenues for our Words+ subsidiary decreased 9.2% to $692,000 from $762,000 in the third quarter of fiscal year 2005. SG&A increased by approximately 23.3% to $795,000 in the second quarter of fiscal 2006, compared to $645,000 in the second quarter of fiscal year 2005, primarily as a result of costs associated with our acquisition of certain secured assets of Bioreason, Inc. in November 2005, as well as salary increases, increases in health insurance, moving expenses to move to our new building, and recruiting costs. In addition, with this quarter, we have now begun to accrue annual bonuses to officers on a quarterly basis, while in the past it was reflected only at the end of the fiscal year when the final earnings were known. Net income before taxes increased 106.3% to $460,000 from $223,000 in the third quarter of fiscal year 2005. Third quarter earnings were also impacted by a provision for income taxes of $74,000 that will not actually be paid, but rather will be a write-off from our deferred tax asset. Consolidated net earnings for the quarter increased 123.1% to $386,000, or $0.09 per diluted share, as compared to net earnings of $173,000, or $0.04 per diluted share for the third quarter of fiscal year 2005."

"For the first nine months, revenues were $4,089,000, an increase of 16.1% over $3,523,000 for the first nine months of fiscal year 2005. Sales of pharmaceutical software licenses and services were $2,179,000, an increase of 36.5% over $1,596,000 in the first nine months of fiscal year 2005, while Words+ sales were $1,910,000, a decrease of 0.9% from $1,927,000 in the previous fiscal year. Net income before taxes increased 103.5% for the first nine months compared to last fiscal year. Net earnings for the first nine months were $436,000, or $0.11 per diluted share, an increase of 112.7% over $205,000, or $0.05 per diluted share for the first nine months of fiscal year 2005. Shareholders' equity at the end of the first nine months increased 13.6% to $5,401,000, as compared to $4,753,000 for the third quarter of fiscal year 2005. It's worth noting that although Words+ sales were very slightly lower, the profitability of Words+ increased 31.5% from $108,000 to $142,000 for the first nine months."

Walt Woltosz, chairman and chief executive officer of Simulations Plus, noted: "Clearly, we're very pleased to report another record quarter and substantial growth over last year. We believe that Simulations Plus is poised with the right kinds of software products at the right time in the industry, when adoption of simulation and modeling tools appears to be on an upswing. In addition to the encouragement provided by the FDA's Critical Path Initiative, the state-of-the-art capabilities of modern simulation and modeling software make it almost imperative for pharmaceutical, biotech, generic, and drug delivery companies to use these powerful tools to avoid the extreme waste that has been typical of pharmaceutical research and development in the past. Simulations Plus continues to refine our existing software product line as well as to look for new opportunities both inside and outside the company to expand our offerings both in number and in scope. We are currently hiring several additional scientists in order to handle our growing consulting business, to increase our marketing and sales capabilities, and to expand our R&D efforts."

About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery and development simulation software, which is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies worldwide. The Company's Words+ subsidiary produces assistive technology and communication devices for persons with disabilities. The Company also produces a line of educational simulation software under the umbrella name FutureLab(TM), which is based on its proprietary software technologies. Simulations Plus, Inc., is headquartered in Southern California. For more information, visit our Web sites at www.simulations-plus.com and www.words-plus.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995
With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. The actual future results of the Company could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: the ability of the Company to continue to book revenues and earnings in accordance with existing accounting standards, the ability of the Company to maintain its competitive advantage, the general economics of the disability and pharmaceutical industries, the ability of the Company to attract and maintain sufficient scientific and technical staff to sustain its R&D and customer support functions, and a sustainable market. Further information on the Company's risk factors is contained in the Company's quarterly and annual reports as filed with the Securities and Exchange Commission.


Simulations Plus, Inc. and Subsidiary

Consolidated Balance Sheet

At May 31, 2006

(Unaudited)

ASSETS

Current assets

Cash and cash equivalents

$ 1,099,182

Accounts receivable, net of allowance for doubtful accounts

of $20,160

1,571,312

Inventory

231,870

Prepaid expenses and other current assets

54,759

Current portion of deferred tax

83,000

Total current assets

3,040,123

Capitalized computer software development costs,

net of accumulated amortization of $2,342,391

1,322,203

Long term contracts receivable, net of discounts of $6,787

294,373

Property and equipment, net

102,783

Customer relationships

109,216

Deferred tax

1,145,739

Other assets

19,470

Total assets

$ 6,033,907

LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities

Accounts payable

$ 159,410

Accrued payroll and other expenses

308,589

Accrued bonuses to officers

57,681

Accrued warranty and service costs

32,463

Current portion of deferred revenue

73,298

Other current liabilities

1,157

Total current liabilities

632,598

Deferred revenue

-

Total liabilities

632,598

Commitments and contingencies

-

Shareholders' equity

Preferred stock, $0.001 par value

10,000,000 shares authorized

no shares issued and outstanding

-

Common stock, $0.001 par value

20,000,000 shares authorized

3,702,748 shares issued and outstanding

3,703

Additional paid-in capital

5,246,954

Retained Earnings

150,652

Total shareholders' equity

5,401,309

Total liabilities and shareholders' equity

$ 6,033,907


Simulations Plus, Inc. and Subsidiary

Consolidated Statements of Operations

For the three and nine months ended May 31,

(Unaudited)

Three months ended

Nine months ended

2006

2005

2006

2005

Net sales

$ 1,788,284

$ 1,424,438

$ 4,088,890

$ 3,522,688

Cost of sales

433,496

428,266

1,152,160

1,121,190

Gross profit

1,354,788

996,172

2,936,730

2,401,498

Operating expenses

Selling, general, and administrative

795,547

644,502

2,112,040

1,811,889

Research and development

118,707

134,007

335,642

378,926

Total operating expenses

914,254

778,509

2,447,682

2,190,815

Income from operations

440,534

217,663

489,048

210,683

Other income (expense)

Interest income

4,447

7,114

13,549

38,410

Miscellaneous income

58

1,189

108

1,189

Interest expense

(40)

(259)

(40)

(543)

Gain on sale of assets

4,613

2,201

7,739

7,401

Gain (loss) on currency exchange

10,076

(4,658)

8,727

(2,547)

Total other income (expense)

19,154

5,587

30,083

43,910

Income before benefit from (provision for) income taxes

459,688

223,250

519,131

254,593

Benefit from (provision for) income taxes

Provision for income tax

(73,550)

(50,000)

(83,061)

(50,000)

Change in valuation allowance

-

-

-

-

Total benefit from (provision for) income taxes

(73,550)

(50,000)

(83,061)

(50,000)

Net income

$ 386,138

$ 173,250

$ 436,070

$ 204,593

Basic earnings per share

$ 0.10

$ 0.05

$ 0.12

$ 0.06

Diluted earnings per share

$ 0.09

$ 0.04

$ 0.11

$ 0.05

Weighted-average common shares outstanding

Basic

3,695,771

3,627,811

3,672,009

3,602,605

Diluted

4,113,033

3,958,063

4,052,480

3,958,063




For further information:

Simulations Plus, Inc.
42505 10th Street West
Lancaster, CA
93534-7059 USA
www.simulations-plus.com
CONTACT: investor relations:
Contact: Renee Bouche